Elanco Animal Health has announced that Galliprant (grapiprant tablets), a first-in-class piprant, is now available to veterinarians for once-daily use in dogs with osteoarthritis (OA), according to a company release. Galliprant can be used in patients as young as 9 months weighing 8 pounds or more, and most dogs can be dosed once a day with a whole or half tablet.
Galliprant is the first piprant (a non-COX-inhibiting prostaglandin receptor antagonist, or PRA) approved for use in veterinary medicine, the release states. It targets the clinical signs of OA by specifically blocking the prostaglandin EP4 receptor, which is the primary mediator of OA pain and inflammation, while not inhibiting the production of housekeeping prostanoids that maintain homeostatic functions.
Galliprant was developed by Aratana Therapeutics and received approval from the U.S. Food and Drug Administration in 2016. Elanco subsequently obtained exclusive rights to develop, manufacture and market Galliprant globally, and it co-promotes the product with Aratana in the United States.