Merial has received FDA approval for administration of a loading dose (a larger dose on the first day) of Marquis (15% w/w ponazuril) to begin treatment for equine protozoal myeloencephalitis (EPM). Administration of the loading dose allows Marquis concentrations to approach a steady state, when the rate of input is equal to the rate of elimination, within one to two days, as opposed to eight days using the originally approved dosage regimen. The syringe is calibrated for a single dose, based on the weight of the horse. On the first day of treatment, three doses are administered, then the maintenance dose is continued for 27 days of treatment. 

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